Pharmacokinetics: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Pharmacokinetics

Sample item

What does first-pass metabolism reduce after oral drug administration?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Systemic bioavailability

First-pass metabolism in gut wall and liver can metabolize a drug before it reaches systemic circulation, reducing oral bioavailability.

Option by option

  • A. Volume of distribution only

    Distribution occurs after systemic entry.

  • B. Renal filtration rate

    Renal filtration is a separate elimination process.

  • C. Protein binding only

    Protein binding is not the direct first-pass effect.

  • D. Systemic bioavailability (correct)

    Correct: presystemic metabolism lowers fraction reaching circulation.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is D, Systemic bioavailability. First-pass metabolism in gut wall and liver can metabolize a drug before it reaches systemic circulation, reducing oral bioavailability.

Why is "Volume of distribution only" not the answer?

Distribution occurs after systemic entry.

Why is "Renal filtration rate" not the answer?

Renal filtration is a separate elimination process.

Why is "Protein binding only" not the answer?

Protein binding is not the direct first-pass effect.

What concept does this question test?

It tests Pharmacokinetics in Pharmacology. The correct option holds because: Correct: presystemic metabolism lowers fraction reaching circulation.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Pharmacokinetics?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.