Pharmacogenomics: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Pharmacogenomics

Sample item

Why is HLA testing used before selected medicines?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Identify patients at high risk of severe immune reactions

Specific HLA alleles can predict serious drug hypersensitivity for certain medicines, allowing safer selection before exposure when testing is indicated.

Option by option

  • A. Measure renal drug clearance

    Renal clearance uses kidney-function measures.

  • B. Identify patients at high risk of severe immune reactions (correct)

    Correct: HLA variants can predict immune-mediated toxicity.

  • C. Calculate body surface area only

    Body surface area has other dosing roles.

  • D. Determine antibiotic susceptibility

    Susceptibility testing applies to microbes.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is B, Identify patients at high risk of severe immune reactions. Specific HLA alleles can predict serious drug hypersensitivity for certain medicines, allowing safer selection before exposure when testing is indicated.

Why is "Measure renal drug clearance" not the answer?

Renal clearance uses kidney-function measures.

Why is "Calculate body surface area only" not the answer?

Body surface area has other dosing roles.

Why is "Determine antibiotic susceptibility" not the answer?

Susceptibility testing applies to microbes.

What concept does this question test?

It tests Pharmacogenomics in Pharmacology. The correct option holds because: Correct: HLA variants can predict immune-mediated toxicity.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Pharmacogenomics?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.