Drug interactions: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Drug interactions

Sample item

What interaction occurs when two drugs have additive sedative effects?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Pharmacodynamic interaction

Two CNS depressants can have additive pharmacodynamic effects at different or similar targets, increasing sedation and respiratory-depression risk.

Option by option

  • A. Pharmacogenetic variation only

    Genetics does not explain the immediate combination effect.

  • B. Chemical incompatibility in syringe only

    Syringe incompatibility is formulation-specific.

  • C. Reduced renal clearance only

    Clearance change is a pharmacokinetic interaction.

  • D. Pharmacodynamic interaction (correct)

    Correct: combined physiological effects are pharmacodynamic.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is D, Pharmacodynamic interaction. Two CNS depressants can have additive pharmacodynamic effects at different or similar targets, increasing sedation and respiratory-depression risk.

Why is "Pharmacogenetic variation only" not the answer?

Genetics does not explain the immediate combination effect.

Why is "Chemical incompatibility in syringe only" not the answer?

Syringe incompatibility is formulation-specific.

Why is "Reduced renal clearance only" not the answer?

Clearance change is a pharmacokinetic interaction.

What concept does this question test?

It tests Drug interactions in Pharmacology. The correct option holds because: Correct: combined physiological effects are pharmacodynamic.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Drug interactions?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.