Antifungal drugs: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Antifungal drugs

Sample item

What fungal component is targeted by amphotericin B?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Ergosterol in cell membrane

Amphotericin B binds fungal ergosterol and forms membrane pores, causing leakage of intracellular contents but also potential renal toxicity.

Option by option

  • A. Ergosterol in cell membrane (correct)

    Correct: ergosterol binding creates membrane pores.

  • B. Peptidoglycan cell wall

    Peptidoglycan is bacterial.

  • C. Viral capsid

    Capsids are viral structures.

  • D. Bacterial folate enzyme

    Folate enzymes are targeted by other antimicrobials.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is A, Ergosterol in cell membrane. Amphotericin B binds fungal ergosterol and forms membrane pores, causing leakage of intracellular contents but also potential renal toxicity.

Why is "Peptidoglycan cell wall" not the answer?

Peptidoglycan is bacterial.

Why is "Viral capsid" not the answer?

Capsids are viral structures.

Why is "Bacterial folate enzyme" not the answer?

Folate enzymes are targeted by other antimicrobials.

What concept does this question test?

It tests Antifungal drugs in Pharmacology. The correct option holds because: Correct: ergosterol binding creates membrane pores.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antifungal drugs?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.