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Anatomy · Embryology: neural tube
Sample itemFailure of closure of the caudal neuropore most directly causes which defect?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Spina bifida
The caudal neuropore gives rise to lower neural-tube structures, and failure of closure causes spinal dysraphism such as spina bifida. Failure of rostral neuropore closure causes anencephaly.
Option by option
A. Spina bifida (correct)
Correct. Caudal neuropore closure failure causes spinal neural-tube defects.
B. Tracheoesophageal fistula
Tracheoesophageal fistula arises from abnormal foregut partitioning.
C. Anencephaly
Anencephaly results from rostral neuropore failure.
D. Cleft lip
Cleft lip results from facial-process fusion failure.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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