Embryology: neural tube: practice question

A Anatomy question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anatomy · Embryology: neural tube

Sample item

Failure of closure of the caudal neuropore most directly causes which defect?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Spina bifida

The caudal neuropore gives rise to lower neural-tube structures, and failure of closure causes spinal dysraphism such as spina bifida. Failure of rostral neuropore closure causes anencephaly.

Option by option

  • A. Spina bifida (correct)

    Correct. Caudal neuropore closure failure causes spinal neural-tube defects.

  • B. Tracheoesophageal fistula

    Tracheoesophageal fistula arises from abnormal foregut partitioning.

  • C. Anencephaly

    Anencephaly results from rostral neuropore failure.

  • D. Cleft lip

    Cleft lip results from facial-process fusion failure.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Anatomy question

What is the answer to this Anatomy question?

The best answer is A, Spina bifida. The caudal neuropore gives rise to lower neural-tube structures, and failure of closure causes spinal dysraphism such as spina bifida.

Why is "Tracheoesophageal fistula" not the answer?

Tracheoesophageal fistula arises from abnormal foregut partitioning.

Why is "Anencephaly" not the answer?

Anencephaly results from rostral neuropore failure.

Why is "Cleft lip" not the answer?

Cleft lip results from facial-process fusion failure.

What concept does this question test?

It tests Embryology: neural tube in Anatomy. Failure of rostral neuropore closure causes anencephaly.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Embryology: neural tube?

Learn every nerve by its route, its muscles and what a lesion looks like at the bedside. That one habit answers a large share of questions. Then use the flashcards and the other Anatomy questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.