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Physiology · Membrane physiology: resting potential
Sample itemWhich ion has the greatest influence on the resting membrane potential of a typical neuron?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Potassium
At rest, neuronal membranes are most permeable to potassium through leak channels, so the resting potential lies close to the potassium equilibrium potential. Sodium permeability rises sharply during the action potential upstroke.
Option by option
A. Sodium
Sodium dominates the rapid depolarization phase rather than resting potential.
B. Calcium
Calcium is tightly regulated and has lower resting permeability.
C. Potassium (correct)
Correct. Potassium leak conductance dominates at rest.
D. Chloride only
Chloride contributes in some cells but is not the principal determinant here.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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