Membrane physiology: resting potential: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Physiology · Membrane physiology: resting potential

Sample item

Which ion has the greatest influence on the resting membrane potential of a typical neuron?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Potassium

At rest, neuronal membranes are most permeable to potassium through leak channels, so the resting potential lies close to the potassium equilibrium potential. Sodium permeability rises sharply during the action potential upstroke.

Option by option

  • A. Sodium

    Sodium dominates the rapid depolarization phase rather than resting potential.

  • B. Calcium

    Calcium is tightly regulated and has lower resting permeability.

  • C. Potassium (correct)

    Correct. Potassium leak conductance dominates at rest.

  • D. Chloride only

    Chloride contributes in some cells but is not the principal determinant here.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is C, Potassium. At rest, neuronal membranes are most permeable to potassium through leak channels, so the resting potential lies close to the potassium equilibrium potential.

Why is "Sodium" not the answer?

Sodium dominates the rapid depolarization phase rather than resting potential.

Why is "Calcium" not the answer?

Calcium is tightly regulated and has lower resting permeability.

Why is "Chloride only" not the answer?

Chloride contributes in some cells but is not the principal determinant here.

What concept does this question test?

It tests Membrane physiology: resting potential in Physiology. Sodium permeability rises sharply during the action potential upstroke.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Membrane physiology: resting potential?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.