Try it
Physiology · Renal physiology: acid-base handling
Sample itemWhich nephron segment secretes the largest fraction of filtered bicarbonate back into the blood through reabsorption?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Proximal convoluted tubule
Most filtered bicarbonate is reclaimed in the proximal convoluted tubule through carbonic anhydrase-dependent processes. Distal nephron segments fine-tune acid excretion and bicarbonate handling.
Option by option
A. Thick ascending limb only
Thick ascending limb reabsorbs salt but not most bicarbonate.
B. Collecting duct only
Collecting duct fine-tunes acid-base balance.
C. Thin descending limb
Thin descending limb is highly water permeable.
D. Proximal convoluted tubule (correct)
Correct. Proximal tubule is the major bicarbonate-reabsorbing segment.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
More Physiology questions
- Cardiac cycleDuring which phase of the cardiac cycle are all valves closed while ventricular pressure…
- Renal physiologyWhich substance is freely filtered and neither reabsorbed nor secreted, so that its clea…
- RespirationWhich of the following shifts the oxygen–haemoglobin dissociation curve to the right?
- Renal physiologyWhich of the following favours glomerular filtration?