Renal physiology: acid-base handling: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Physiology · Renal physiology: acid-base handling

Sample item

Which nephron segment secretes the largest fraction of filtered bicarbonate back into the blood through reabsorption?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Proximal convoluted tubule

Most filtered bicarbonate is reclaimed in the proximal convoluted tubule through carbonic anhydrase-dependent processes. Distal nephron segments fine-tune acid excretion and bicarbonate handling.

Option by option

  • A. Thick ascending limb only

    Thick ascending limb reabsorbs salt but not most bicarbonate.

  • B. Collecting duct only

    Collecting duct fine-tunes acid-base balance.

  • C. Thin descending limb

    Thin descending limb is highly water permeable.

  • D. Proximal convoluted tubule (correct)

    Correct. Proximal tubule is the major bicarbonate-reabsorbing segment.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is D, Proximal convoluted tubule. Most filtered bicarbonate is reclaimed in the proximal convoluted tubule through carbonic anhydrase-dependent processes.

Why is "Thick ascending limb only" not the answer?

Thick ascending limb reabsorbs salt but not most bicarbonate.

Why is "Collecting duct only" not the answer?

Collecting duct fine-tunes acid-base balance.

Why is "Thin descending limb" not the answer?

Thin descending limb is highly water permeable.

What concept does this question test?

It tests Renal physiology: acid-base handling in Physiology. Distal nephron segments fine-tune acid excretion and bicarbonate handling.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Renal physiology: acid-base handling?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.