Gynecology: premature ovarian insufficiency: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Gynecology: premature ovarian insufficiency

Sample item

A 34-year-old has amenorrhea, hot flushes, elevated FSH on repeated testing, and low estradiol. What diagnosis is most likely?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Premature ovarian insufficiency

Premature ovarian insufficiency is loss of ovarian activity before age 40, with menstrual disturbance, elevated gonadotropins, and low estrogen. It affects fertility, bone, and cardiovascular health.

Option by option

  • A. Polycystic ovary syndrome

    PCOS usually has ongoing estrogen exposure and normal or low FSH.

  • B. Hyperprolactinemia only

    Hyperprolactinemia suppresses gonadotropins rather than raising FSH.

  • C. Pregnancy

    Pregnancy has different hormonal findings.

  • D. Premature ovarian insufficiency (correct)

    Correct. High FSH and low estradiol before 40 support ovarian insufficiency.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this OBG question

What is the answer to this OBG question?

The best answer is D, Premature ovarian insufficiency. Premature ovarian insufficiency is loss of ovarian activity before age 40, with menstrual disturbance, elevated gonadotropins, and low estrogen.

Why is "Polycystic ovary syndrome" not the answer?

PCOS usually has ongoing estrogen exposure and normal or low FSH.

Why is "Hyperprolactinemia only" not the answer?

Hyperprolactinemia suppresses gonadotropins rather than raising FSH.

Why is "Pregnancy" not the answer?

Pregnancy has different hormonal findings.

What concept does this question test?

It tests Gynecology: premature ovarian insufficiency in OBG. It affects fertility, bone, and cardiovascular health.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gynecology: premature ovarian insufficiency?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.