Collagen synthesis: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

Biochemistry · Collagen synthesis

Sample item

Which vitamin is required for hydroxylation of proline and lysine during collagen synthesis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Vitamin C

Vitamin C is a cofactor for prolyl and lysyl hydroxylases in collagen maturation. Deficiency weakens connective tissue and causes bleeding gums, bruising, and impaired wound healing.

Option by option

  • A. Vitamin B12

    Vitamin B12 is required for DNA synthesis and myelin-related pathways.

  • B. Vitamin C (correct)

    Correct. Ascorbate is essential for stable collagen cross-linking.

  • C. Vitamin K

    Vitamin K supports gamma-carboxylation of coagulation factors.

  • D. Vitamin D

    Vitamin D regulates calcium and bone mineralization.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Biochemistry questions

Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is B, Vitamin C. Vitamin C is a cofactor for prolyl and lysyl hydroxylases in collagen maturation.

Why is "Vitamin B12" not the answer?

Vitamin B12 is required for DNA synthesis and myelin-related pathways.

Why is "Vitamin K" not the answer?

Vitamin K supports gamma-carboxylation of coagulation factors.

Why is "Vitamin D" not the answer?

Vitamin D regulates calcium and bone mineralization.

What concept does this question test?

It tests Collagen synthesis in Biochemistry. Deficiency weakens connective tissue and causes bleeding gums, bruising, and impaired wound healing.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Collagen synthesis?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.