Collagen disorders: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

Biochemistry · Collagen disorders

Sample item

A child has hyperextensible skin, joint hypermobility, and easy bruising due to defective collagen processing. What disorder is most likely?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Ehlers-Danlos syndrome

Ehlers-Danlos syndromes are inherited connective-tissue disorders involving collagen structure or processing and commonly cause skin hyperextensibility, joint hypermobility, and tissue fragility.

Option by option

  • A. Osteogenesis imperfecta

    Osteogenesis imperfecta is a type I collagen disorder dominated by bone fragility.

  • B. Ehlers-Danlos syndrome (correct)

    Correct. The skin and joint phenotype is characteristic Ehlers-Danlos syndrome.

  • C. Marfan syndrome

    Marfan syndrome involves fibrillin and often causes lens and aortic disease.

  • D. Scurvy only

    Scurvy is acquired vitamin C deficiency, not an inherited collagen-processing defect.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Biochemistry questions

Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is B, Ehlers-Danlos syndrome. Ehlers-Danlos syndromes are inherited connective-tissue disorders involving collagen structure or processing and commonly cause skin hyperextensibility, joint hypermobility, and tissue fragility.

Why is "Osteogenesis imperfecta" not the answer?

Osteogenesis imperfecta is a type I collagen disorder dominated by bone fragility.

Why is "Marfan syndrome" not the answer?

Marfan syndrome involves fibrillin and often causes lens and aortic disease.

Why is "Scurvy only" not the answer?

Scurvy is acquired vitamin C deficiency, not an inherited collagen-processing defect.

What concept does this question test?

It tests Collagen disorders in Biochemistry. The correct option holds because: Correct. The skin and joint phenotype is characteristic Ehlers-Danlos syndrome.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Collagen disorders?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.