Pharmacovigilance: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Pharmacovigilance

Sample item

What is a dechallenge in suspected adverse drug reaction assessment?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Improvement after stopping suspected medicine

Dechallenge refers to observing whether an adverse event improves after withdrawal of a suspected medicine, supporting but not proving causality.

Option by option

  • A. Giving larger dose to test safety

    Dose escalation may be unsafe.

  • B. Reappearance after re-exposure only

    Reappearance after re-exposure is rechallenge.

  • C. Improvement after stopping suspected medicine (correct)

    Correct: stopping drug and observing improvement is dechallenge.

  • D. Measuring drug price change

    Pricing is unrelated.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is C, Improvement after stopping suspected medicine. Dechallenge refers to observing whether an adverse event improves after withdrawal of a suspected medicine, supporting but not proving causality.

Why is "Giving larger dose to test safety" not the answer?

Dose escalation may be unsafe.

Why is "Reappearance after re-exposure only" not the answer?

Reappearance after re-exposure is rechallenge.

Why is "Measuring drug price change" not the answer?

Pricing is unrelated.

What concept does this question test?

It tests Pharmacovigilance in Pharmacology. The correct option holds because: Correct: stopping drug and observing improvement is dechallenge.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Pharmacovigilance?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.