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Radiology · Breast imaging
Sample itemA screening mammogram in a 52-year-old woman shows a cluster of fine, pleomorphic, linear branching microcalcifications without any mass. Core biopsy is most likely to show:
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Ductal carcinoma in situ
Fine pleomorphic or linear branching microcalcifications in a segmental or clustered distribution are suspicious for DCIS, as comedo-type necrosis calcifies. Stereotactic biopsy confirms the diagnosis. Coarse popcorn calcifications suggest a degenerating fibroadenoma, and eggshell calcification suggests fat necrosis or cysts.
Option by option
A. Fibroadenoma
Fibroadenomas calcify coarsely, in a popcorn pattern.
B. Fat necrosis
Fat necrosis classically shows lucent-centred or eggshell calcification.
C. Ductal carcinoma in situ (correct)
Correct. Clustered pleomorphic branching calcifications point to DCIS.
D. Simple cyst
Simple cysts have no suspicious microcalcifications and appear as anechoic on ultrasound.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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