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Ophthalmology · Sclera: scleritis
Sample itemA 55-year-old woman with rheumatoid arthritis has a severe, deep, boring eye pain that wakes her at night and radiates to the brow. The eye is red with a violaceous hue and tenderness. After instilling 10% phenylephrine, the redness does not blanch. What is the diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Scleritis
Scleritis is inflammation of the sclera, often associated with rheumatoid arthritis, granulomatosis with polyangiitis or other systemic vasculitis. It causes severe boring pain, a deep violaceous redness that does not blanch with phenylephrine, and a risk of scleral thinning (scleromalacia) and perforation. Treatment is systemic NSAIDs or corticosteroids, with immunosuppression for necrotising disease. Episcleritis is milder, with superficial vessels that blanch.
Option by option
A. Acute angle-closure glaucoma
Angle-closure glaucoma causes a fixed mid-dilated pupil, a hazy cornea and very high pressure.
B. Acute conjunctivitis
Conjunctivitis produces discharge and gritty irritation, not severe boring pain.
C. Scleritis (correct)
Correct. Deep, non-blanching redness with severe night pain is typical of scleritis.
D. Episcleritis
Episcleritis causes mild discomfort and superficial redness that blanches with phenylephrine.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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