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Anatomy · Pelvis: prostate zones
Sample itemA 68-year-old man has a weak stream and nocturia, and rectal examination shows a smooth, symmetrically enlarged prostate. Which zone enlarges to compress the urethra, and where do most prostate carcinomas arise?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Transition zone enlarges; carcinoma arises mainly in the peripheral zone
Benign prostatic hyperplasia arises in the transition zone, which surrounds the proximal urethra, and compresses it to produce obstructive symptoms. Most adenocarcinomas arise in the peripheral zone, the posterior part felt on digital rectal examination. The central zone surrounds the ejaculatory ducts.
Option by option
A. Central zone enlarges; carcinoma arises mainly in the transition zone
The central zone is not the main site of BPH, and only a minority of carcinomas arise in the transition zone.
B. Transition zone enlarges; carcinoma arises mainly in the peripheral zone (correct)
Correct. BPH is a transition zone disease and carcinoma is mainly peripheral.
C. Transition zone enlarges; carcinoma arises mainly in the central zone
BPH is correctly assigned, but carcinoma is mostly peripheral, not central.
D. Peripheral zone enlarges; carcinoma arises mainly in the transition zone
The peripheral zone is the usual site of carcinoma, not BPH.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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