Neuroanatomy: subthalamic nucleus: practice question

A Anatomy question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anatomy · Neuroanatomy: subthalamic nucleus

Sample item

A 70-year-old hypertensive woman suddenly develops violent, flinging movements of the right arm and leg. Where is the lesion most likely to be?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Left subthalamic nucleus

Hemiballismus is caused by a small infarct or haemorrhage of the contralateral subthalamic nucleus, which normally excites the internal pallidum and so suppresses unwanted movements. Loss of this drive disinhibits the thalamus and cortex. The lesion is on the opposite side to the flinging limbs.

Option by option

  • A. Left subthalamic nucleus (correct)

    A left subthalamic lesion produces right-sided hemiballismus.

  • B. Right substantia nigra

    Substantia nigra degeneration produces parkinsonism with rigidity and tremor.

  • C. Left caudate nucleus

    Caudate degeneration produces chorea, as in Huntington disease, not ballistic flinging.

  • D. Right subthalamic nucleus

    A right subthalamic lesion would produce movements on the left side.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Anatomy question

What is the answer to this Anatomy question?

The best answer is A, Left subthalamic nucleus. Hemiballismus is caused by a small infarct or haemorrhage of the contralateral subthalamic nucleus, which normally excites the internal pallidum and so suppresses unwanted movements.

Why is "Right substantia nigra" not the answer?

Substantia nigra degeneration produces parkinsonism with rigidity and tremor.

Why is "Left caudate nucleus" not the answer?

Caudate degeneration produces chorea, as in Huntington disease, not ballistic flinging.

Why is "Right subthalamic nucleus" not the answer?

A right subthalamic lesion would produce movements on the left side.

What concept does this question test?

It tests Neuroanatomy: subthalamic nucleus in Anatomy. Loss of this drive disinhibits the thalamus and cortex. The lesion is on the opposite side to the flinging limbs.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Neuroanatomy: subthalamic nucleus?

Learn every nerve by its route, its muscles and what a lesion looks like at the bedside. That one habit answers a large share of questions. Then use the flashcards and the other Anatomy questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.