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Anatomy · Neuroanatomy: subthalamic nucleus
Sample itemA 70-year-old hypertensive woman suddenly develops violent, flinging movements of the right arm and leg. Where is the lesion most likely to be?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Left subthalamic nucleus
Hemiballismus is caused by a small infarct or haemorrhage of the contralateral subthalamic nucleus, which normally excites the internal pallidum and so suppresses unwanted movements. Loss of this drive disinhibits the thalamus and cortex. The lesion is on the opposite side to the flinging limbs.
Option by option
A. Left subthalamic nucleus (correct)
A left subthalamic lesion produces right-sided hemiballismus.
B. Right substantia nigra
Substantia nigra degeneration produces parkinsonism with rigidity and tremor.
C. Left caudate nucleus
Caudate degeneration produces chorea, as in Huntington disease, not ballistic flinging.
D. Right subthalamic nucleus
A right subthalamic lesion would produce movements on the left side.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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