Normal pregnancy and antenatal care: nausea and vomiting of pregnancy: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Normal pregnancy and antenatal care: nausea and vomiting of pregnancy

Sample item

A woman at 8 weeks has persistent nausea and vomiting with no dehydration or ketonuria. Dietary advice has failed. Which medication is a first-line drug?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Doxylamine with pyridoxine

The combination of doxylamine and pyridoxine is the usual first-line drug treatment for nausea and vomiting of pregnancy and has good safety data. Ondansetron, metoclopramide and corticosteroids are kept for failures or severe cases such as hyperemesis gravidarum.

Option by option

  • A. Ondansetron

    Ondansetron is a second-line agent because of limited data in the first trimester.

  • B. Doxylamine with pyridoxine (correct)

    Correct. Doxylamine and pyridoxine is the standard first-line combination.

  • C. Prednisolone

    Corticosteroids are a last resort in refractory hyperemesis and are avoided early in pregnancy.

  • D. Domperidone with omeprazole

    Domperidone and omeprazole address reflux and gastric emptying and are not the first-line treatment.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is B, Doxylamine with pyridoxine. The combination of doxylamine and pyridoxine is the usual first-line drug treatment for nausea and vomiting of pregnancy and has good safety data.

Why is "Ondansetron" not the answer?

Ondansetron is a second-line agent because of limited data in the first trimester.

Why is "Prednisolone" not the answer?

Corticosteroids are a last resort in refractory hyperemesis and are avoided early in pregnancy.

Why is "Domperidone with omeprazole" not the answer?

Domperidone and omeprazole address reflux and gastric emptying and are not the first-line treatment.

What concept does this question test?

It tests Normal pregnancy and antenatal care: nausea and vomiting of pregnancy in OBG. Ondansetron, metoclopramide and corticosteroids are kept for failures or severe cases such as hyperemesis gravidarum.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Normal pregnancy and antenatal care: nausea and vomiting of pregnancy?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.