Uvea: biologic therapy for juvenile arthritis uveitis: practice question

A Ophthalmology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Ophthalmology · Uvea: biologic therapy for juvenile arthritis uveitis

Sample item

A 9-year-old girl with oligoarticular juvenile idiopathic arthritis has chronic anterior uveitis that keeps relapsing despite topical steroids and methotrexate. Which agent has the best evidence as the next step?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Adalimumab

Adalimumab, a monoclonal anti-TNF antibody, has trial support for steroid-sparing control of chronic uveitis in juvenile idiopathic arthritis that fails methotrexate, and it also treats other severe non-infectious uveitis such as Behcet disease.

Option by option

  • A. Oral doxycycline

    Doxycycline has no role in controlling immune-mediated uveitis.

  • B. Oral acyclovir

    Acyclovir treats herpetic uveitis, which is not the cause here.

  • C. Adalimumab (correct)

    Correct. Anti-TNF therapy with adalimumab is the evidence-based escalation.

  • D. Topical cyclosporine 0.05 percent

    Topical cyclosporine treats dry eye and surface disease and does not control intraocular inflammation.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Ophthalmology question

What is the answer to this Ophthalmology question?

The best answer is C, Adalimumab. Adalimumab, a monoclonal anti-TNF antibody, has trial support for steroid-sparing control of chronic uveitis in juvenile idiopathic arthritis that fails methotrexate, and it also treats other severe non-infectious uveitis such as Behcet disease.

Why is "Oral doxycycline" not the answer?

Doxycycline has no role in controlling immune-mediated uveitis.

Why is "Oral acyclovir" not the answer?

Acyclovir treats herpetic uveitis, which is not the cause here.

Why is "Topical cyclosporine 0.05 percent" not the answer?

Topical cyclosporine treats dry eye and surface disease and does not control intraocular inflammation.

What concept does this question test?

It tests Uvea: biologic therapy for juvenile arthritis uveitis in Ophthalmology. The correct option holds because: Correct. Anti-TNF therapy with adalimumab is the evidence-based escalation.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Uvea: biologic therapy for juvenile arthritis uveitis?

Group the red eye by what to examine and what the pupil does. Then use the flashcards and the other Ophthalmology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.