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Psychiatry · Psychopharmacology: levetiracetam behavioural effects
Sample itemA patient with epilepsy is started on a new anticonvulsant. Within weeks his family reports irritability, aggression and low mood that were not there before. Which drug is the best-known cause?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Levetiracetam
Levetiracetam is well known for behavioural adverse effects including irritability, aggression, anxiety, depression and occasionally psychosis. Lamotrigine and carbamazepine tend to stabilise mood.
Option by option
A. Phenytoin
Phenytoin chiefly causes gingival hyperplasia, hirsutism, ataxia and nystagmus.
B. Lamotrigine
Lamotrigine has mood-stabilising effects and its main hazard is rash.
C. Carbamazepine
Carbamazepine is a mood stabiliser; its typical problems are hyponatraemia and rash.
D. Levetiracetam (correct)
Correct. Irritability and depression are characteristic of levetiracetam.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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