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Dentistry · Oral medicine and oral cancer: field cancerisation
Sample itemA man treated for an early tongue carcinoma with clear margins develops a new carcinoma on the floor of the mouth four years later, with a different histological pattern. Which concept explains this?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Field cancerisation
Field cancerisation means that long-term carcinogen exposure such as tobacco and areca nut affects the entire mucosal field and produces multiple, independent primary tumours. This is why patients with oral cancer need lifelong surveillance and cessation counselling.
Option by option
A. Implantation of cells at surgery
Implantation at surgery would occur in the wound and not at a distant mucosal site.
B. Field cancerisation (correct)
Correct. The exposed mucosa as a whole is at risk, producing separate primaries.
C. Local recurrence from positive margin
A positive margin gives recurrence at the original site with the same pattern.
D. Lymphatic metastasis
Lymphatic spread appears in nodes rather than as a new mucosal primary.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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