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ENT · Nose and paranasal sinuses: non-allergic rhinitis with eosinophilia
Sample itemA 40-year-old has perennial sneezing and profuse watery rhinorrhoea. Skin prick tests are negative and serum total IgE is normal, but nasal smear shows many eosinophils. What is the most likely diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Non-allergic rhinitis with eosinophilia syndrome
Non-allergic rhinitis with eosinophilia syndrome (NARES) mimics allergic rhinitis, with many nasal eosinophils but negative allergy tests. It responds well to intranasal corticosteroids and may precede aspirin sensitivity and polyposis. Vasomotor rhinitis lacks eosinophils.
Option by option
A. Vasomotor rhinitis
Vasomotor rhinitis has a smear without eosinophils.
B. Allergic rhinitis
Allergic rhinitis requires a positive skin test or specific IgE.
C. Non-allergic rhinitis with eosinophilia syndrome (correct)
Correct. Nasal eosinophilia with negative allergy testing defines this condition.
D. Infective rhinitis
Infective rhinitis shows neutrophils and a short illness.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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