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OBG · Postpartum haemorrhage and emergencies: choriocarcinoma after term delivery
Sample itemSix weeks after a normal term delivery, a woman has irregular heavy bleeding. The uterus is bulky and soft, and chest X-ray shows multiple round opacities. Curettage tissue is non-diagnostic. Which investigation should be sent next?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Serum beta-hCG
Persistent or recurrent bleeding after any pregnancy, including a normal term birth, with lung metastases should prompt a beta-hCG measurement. A very high level confirms gestational choriocarcinoma, which is treated with chemotherapy. Histology can be unhelpful because of necrosis.
Option by option
A. MRI pelvis for adenomyosis
Adenomyosis would not cause multiple round lung opacities.
B. Serum beta-hCG (correct)
Correct. Beta-hCG is the marker that identifies gestational trophoblastic neoplasia, including after term delivery.
C. Coagulation profile
A coagulation profile is relevant to bleeding disorders but does not explain lung nodules and a bulky uterus.
D. Serum progesterone
Progesterone does not identify trophoblastic disease.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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