Hypertensive disorders: renal histology: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

OBG · Hypertensive disorders: renal histology

Sample item

A renal biopsy in a woman with pre-eclampsia shows enlarged glomeruli with bloodless capillary loops. Which finding is characteristic?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Swollen glomerular endothelial cells narrowing the capillary lumina

Glomerular capillary endotheliosis is the renal lesion of pre-eclampsia: endothelial swelling, subendothelial fibrin deposits and narrowed lumina without much inflammation. It resolves after delivery. Crescents, wire loops and humps belong to other glomerular diseases.

Option by option

  • A. Wire-loop lesions with subendothelial immune deposits

    Wire-loop lesions with immune deposits suggest lupus nephritis.

  • B. Swollen glomerular endothelial cells narrowing the capillary lumina (correct)

    Correct. Glomerular endotheliosis is the characteristic lesion.

  • C. Subepithelial humps with neutrophils

    Subepithelial humps with neutrophils are typical of post-infectious glomerulonephritis.

  • D. Crescent formation with fibrin deposits

    Crescents with fibrin indicate rapidly progressive glomerulonephritis.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is B, Swollen glomerular endothelial cells narrowing the capillary lumina. Glomerular capillary endotheliosis is the renal lesion of pre-eclampsia: endothelial swelling, subendothelial fibrin deposits and narrowed lumina without much inflammation.

Why is "Wire-loop lesions with subendothelial immune deposits" not the answer?

Wire-loop lesions with immune deposits suggest lupus nephritis.

Why is "Subepithelial humps with neutrophils" not the answer?

Subepithelial humps with neutrophils are typical of post-infectious glomerulonephritis.

Why is "Crescent formation with fibrin deposits" not the answer?

Crescents with fibrin indicate rapidly progressive glomerulonephritis.

What concept does this question test?

It tests Hypertensive disorders: renal histology in OBG. It resolves after delivery. Crescents, wire loops and humps belong to other glomerular diseases.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Hypertensive disorders: renal histology?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.