Gynaecological endocrinology: central precocious puberty: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Gynaecological endocrinology: central precocious puberty

Sample item

A 6-year-old girl has had breast budding and a growth spurt for 6 months. Bone age is advanced, LH rises markedly after GnRH stimulation, and brain MRI is normal. What is the treatment?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Long-acting GnRH agonist

This is gonadotropin-dependent (central) precocious puberty. Continuous GnRH agonist exposure desensitises pituitary gonadotrophs, halting pubertal progression and slowing bone-age advance so that final height is preserved.

Option by option

  • A. Combined oral contraceptive

    A contraceptive pill adds sex steroid and would worsen bone-age advance.

  • B. Medroxyprogesterone acetate

    Medroxyprogesterone lowers gonadotropins weakly and does not preserve final height.

  • C. Long-acting GnRH agonist (correct)

    Correct. Continuous GnRH agonist down-regulates the pituitary and arrests puberty.

  • D. Letrozole

    Letrozole is used in gonadotropin-independent forms such as McCune-Albright syndrome.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is C, Long-acting GnRH agonist. This is gonadotropin-dependent (central) precocious puberty.

Why is "Combined oral contraceptive" not the answer?

A contraceptive pill adds sex steroid and would worsen bone-age advance.

Why is "Medroxyprogesterone acetate" not the answer?

Medroxyprogesterone lowers gonadotropins weakly and does not preserve final height.

Why is "Letrozole" not the answer?

Letrozole is used in gonadotropin-independent forms such as McCune-Albright syndrome.

What concept does this question test?

It tests Gynaecological endocrinology: central precocious puberty in OBG. Continuous GnRH agonist exposure desensitises pituitary gonadotrophs, halting pubertal progression and slowing bone-age advance so that final height is preserved.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gynaecological endocrinology: central precocious puberty?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.