Gynaecological endocrinology: Y chromosome material in Turner phenotype: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Gynaecological endocrinology: Y chromosome material in Turner phenotype

Sample item

A 16-year-old with Turner phenotype has primary amenorrhoea, streak gonads and a 45,X/46,XY karyotype. What is advised?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Prophylactic bilateral gonadectomy

Gonads containing Y chromosome material carry a substantial risk of gonadoblastoma and dysgerminoma. Streak gonads are removed once the diagnosis is made, and oestrogen replacement is then given for puberty and bone health.

Option by option

  • A. Annual ultrasound surveillance only

    Surveillance cannot reliably detect a gonadoblastoma at a curable stage.

  • B. Prophylactic bilateral gonadectomy (correct)

    Correct. Y-bearing streak gonads are removed because of gonadoblastoma risk.

  • C. Unilateral oophorectomy

    Removing one gonad leaves the other at risk.

  • D. Oestrogen therapy without surgery

    Oestrogen alone leaves the malignancy risk untreated.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this OBG question

What is the answer to this OBG question?

The best answer is B, Prophylactic bilateral gonadectomy. Gonads containing Y chromosome material carry a substantial risk of gonadoblastoma and dysgerminoma.

Why is "Annual ultrasound surveillance only" not the answer?

Surveillance cannot reliably detect a gonadoblastoma at a curable stage.

Why is "Unilateral oophorectomy" not the answer?

Removing one gonad leaves the other at risk.

Why is "Oestrogen therapy without surgery" not the answer?

Oestrogen alone leaves the malignancy risk untreated.

What concept does this question test?

It tests Gynaecological endocrinology: Y chromosome material in Turner phenotype in OBG. Streak gonads are removed once the diagnosis is made, and oestrogen replacement is then given for puberty and bone health.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gynaecological endocrinology: Y chromosome material in Turner phenotype?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.