Infertility and contraception: DMPA and bone mineral density: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Infertility and contraception: DMPA and bone mineral density

Sample item

Which contraceptive is associated with a reversible reduction in bone mineral density with long-term use?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Depot medroxyprogesterone acetate

DMPA suppresses ovarian oestradiol production, so bone mineral density falls during use and partly recovers after stopping. Other methods listed do not materially suppress oestradiol.

Option by option

  • A. Combined oral contraceptive

    Combined pills maintain or slightly improve bone density.

  • B. Depot medroxyprogesterone acetate (correct)

    Correct. DMPA lowers oestradiol and bone density.

  • C. Levonorgestrel intrauterine system

    The LNG-IUS acts locally and does not lower bone density.

  • D. Copper intrauterine device

    A copper device has no hormonal effect on bone.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this OBG question

What is the answer to this OBG question?

The best answer is B, Depot medroxyprogesterone acetate. DMPA suppresses ovarian oestradiol production, so bone mineral density falls during use and partly recovers after stopping.

Why is "Combined oral contraceptive" not the answer?

Combined pills maintain or slightly improve bone density.

Why is "Levonorgestrel intrauterine system" not the answer?

The LNG-IUS acts locally and does not lower bone density.

Why is "Copper intrauterine device" not the answer?

A copper device has no hormonal effect on bone.

What concept does this question test?

It tests Infertility and contraception: DMPA and bone mineral density in OBG. Other methods listed do not materially suppress oestradiol.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Infertility and contraception: DMPA and bone mineral density?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.