Infertility and contraception: hypogonadotropic hypogonadism in men: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Infertility and contraception: hypogonadotropic hypogonadism in men

Sample item

A man with azoospermia has low FSH, low LH and low testosterone, with a normal pituitary MRI, and wants fertility. What is the treatment of choice?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. hCG with recombinant FSH

In hypogonadotropic hypogonadism the testes are normal but unstimulated. hCG replaces LH and drives Leydig cell testosterone, and FSH supports spermatogenesis, often restoring sperm in the ejaculate.

Option by option

  • A. Testosterone enanthate injections

    Exogenous testosterone suppresses gonadotropins and further impairs sperm production.

  • B. hCG with recombinant FSH (correct)

    Correct. hCG with FSH replaces the missing gonadotropins and restores spermatogenesis.

  • C. Varicocelectomy

    A varicocele is not the cause of low gonadotropins.

  • D. Testicular sperm extraction

    Surgical sperm retrieval is unnecessary when medical treatment can work.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is B, hCG with recombinant FSH. In hypogonadotropic hypogonadism the testes are normal but unstimulated.

Why is "Testosterone enanthate injections" not the answer?

Exogenous testosterone suppresses gonadotropins and further impairs sperm production.

Why is "Varicocelectomy" not the answer?

A varicocele is not the cause of low gonadotropins.

Why is "Testicular sperm extraction" not the answer?

Surgical sperm retrieval is unnecessary when medical treatment can work.

What concept does this question test?

It tests Infertility and contraception: hypogonadotropic hypogonadism in men in OBG. hCG replaces LH and drives Leydig cell testosterone, and FSH supports spermatogenesis, often restoring sperm in the ejaculate.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Infertility and contraception: hypogonadotropic hypogonadism in men?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.