Gynaecological oncology: molecular features of type I endometrial cancer: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Gynaecological oncology: molecular features of type I endometrial cancer

Sample item

Which molecular alteration is most typical of endometrioid (type I) endometrial carcinoma?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. PTEN inactivation

PTEN loss is the commonest early event in endometrioid carcinoma and in complex atypical hyperplasia, and it also underlies the endometrial risk in Cowden syndrome. TP53 mutation is typical of serous carcinoma.

Option by option

  • A. RB1 deletion

    RB1 deletion is not a typical driver of endometrioid cancer.

  • B. TP53 mutation

    TP53 mutation is characteristic of serous (type II) carcinoma.

  • C. BRCA1 mutation

    BRCA1 mutation is characteristic of hereditary ovarian cancer.

  • D. PTEN inactivation (correct)

    Correct. PTEN loss is typical of oestrogen-driven endometrioid cancer.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this OBG question

What is the answer to this OBG question?

The best answer is D, PTEN inactivation. PTEN loss is the commonest early event in endometrioid carcinoma and in complex atypical hyperplasia, and it also underlies the endometrial risk in Cowden syndrome.

Why is "RB1 deletion" not the answer?

RB1 deletion is not a typical driver of endometrioid cancer.

Why is "TP53 mutation" not the answer?

TP53 mutation is characteristic of serous (type II) carcinoma.

Why is "BRCA1 mutation" not the answer?

BRCA1 mutation is characteristic of hereditary ovarian cancer.

What concept does this question test?

It tests Gynaecological oncology: molecular features of type I endometrial cancer in OBG. TP53 mutation is typical of serous carcinoma.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gynaecological oncology: molecular features of type I endometrial cancer?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.