Conjunctiva and cornea: Reis-Bucklers dystrophy: practice question

A Ophthalmology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Ophthalmology · Conjunctiva and cornea: Reis-Bucklers dystrophy

Sample item

A 20-year-old has recurrent painful corneal erosions since childhood and bilateral geographic grey-white subepithelial opacities, with reduced vision. Which layer is mainly affected in this dystrophy?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Bowman layer

Reis-Bucklers (corneal dystrophy of Bowman layer type I) begins in early childhood with erosions, and the opacities replace Bowman layer. It is linked to TGFBI mutations, and phototherapeutic keratectomy can remove superficial opacities.

Option by option

  • A. Bowman layer (correct)

    Correct. Bowman layer is the layer replaced by opacities in this dystrophy.

  • B. Endothelium

    Endothelial disease causes oedema, as in Fuchs, and not geographic subepithelial opacities.

  • C. Deep stroma

    Deep stromal deposits characterise lattice, granular and macular dystrophies.

  • D. Descemet membrane

    Descemet involvement is typical of posterior polymorphous and CHED.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Ophthalmology question

What is the answer to this Ophthalmology question?

The best answer is A, Bowman layer. Reis-Bucklers (corneal dystrophy of Bowman layer type I) begins in early childhood with erosions, and the opacities replace Bowman layer.

Why is "Endothelium" not the answer?

Endothelial disease causes oedema, as in Fuchs, and not geographic subepithelial opacities.

Why is "Deep stroma" not the answer?

Deep stromal deposits characterise lattice, granular and macular dystrophies.

Why is "Descemet membrane" not the answer?

Descemet involvement is typical of posterior polymorphous and CHED.

What concept does this question test?

It tests Conjunctiva and cornea: Reis-Bucklers dystrophy in Ophthalmology. It is linked to TGFBI mutations, and phototherapeutic keratectomy can remove superficial opacities.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Conjunctiva and cornea: Reis-Bucklers dystrophy?

Group the red eye by what to examine and what the pupil does. Then use the flashcards and the other Ophthalmology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.