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Ophthalmology · Lens and cataract: phenothiazine deposits
Sample itemA man on long-term high-dose chlorpromazine for schizophrenia shows fine stellate pigment deposits on the anterior lens capsule. How are these best described?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Star-shaped anterior subcapsular pigmentation
Chlorpromazine and other phenothiazines can deposit granular pigment beneath the anterior lens capsule in a stellate pattern in the pupillary zone, often with corneal deposits. Vision is rarely affected, but the dose and duration should be reviewed.
Option by option
A. Star-shaped anterior subcapsular pigmentation (correct)
Correct. Stellate anterior subcapsular pigment is characteristic.
B. Anterior polar white spot
An anterior polar spot is a congenital developmental anomaly.
C. Oil-droplet central reflex
An oil-droplet reflex indicates lenticonus.
D. Posterior subcapsular plaque
Posterior subcapsular plaques are typical of steroids and radiation.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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