Uvea: fluorescein angiography in VKH: practice question

A Ophthalmology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Ophthalmology · Uvea: fluorescein angiography in VKH

Sample item

In the acute uveitic stage of Vogt-Koyanagi-Harada disease, which fluorescein angiographic pattern is typical?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Multiple pinpoint leaks with pooling in subretinal fluid

Acute disease shows multiple tiny leaks at the level of the retinal pigment epithelium that enlarge and pool in the subretinal space. The leaks mirror the diffuse choroidal inflammation and fluid accumulation.

Option by option

  • A. Window defects without leakage

    Window defects without leakage reflect atrophy of the pigment epithelium, as seen in late disease.

  • B. Hypofluorescent lesions that never fill

    Hypofluorescent lesions that never fill suggest non-perfused or blocked areas, which are not typical of the acute stage.

  • C. A leopard-spot pattern sparing the disc

    A leopard-spot pattern is seen in chronic pigment epithelial disease and is not the acute pattern.

  • D. Multiple pinpoint leaks with pooling in subretinal fluid (correct)

    Correct. Pinpoint leaks that enlarge and pool in serous detachments are the acute pattern.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Ophthalmology question

What is the answer to this Ophthalmology question?

The best answer is D, Multiple pinpoint leaks with pooling in subretinal fluid. Acute disease shows multiple tiny leaks at the level of the retinal pigment epithelium that enlarge and pool in the subretinal space.

Why is "Window defects without leakage" not the answer?

Window defects without leakage reflect atrophy of the pigment epithelium, as seen in late disease.

Why is "Hypofluorescent lesions that never fill" not the answer?

Hypofluorescent lesions that never fill suggest non-perfused or blocked areas, which are not typical of the acute stage.

Why is "A leopard-spot pattern sparing the disc" not the answer?

A leopard-spot pattern is seen in chronic pigment epithelial disease and is not the acute pattern.

What concept does this question test?

It tests Uvea: fluorescein angiography in VKH in Ophthalmology. The leaks mirror the diffuse choroidal inflammation and fluid accumulation.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Uvea: fluorescein angiography in VKH?

Group the red eye by what to examine and what the pupil does. Then use the flashcards and the other Ophthalmology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.