Bone tumours: Mazabraud syndrome: practice question

A Orthopaedics question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Orthopaedics · Bone tumours: Mazabraud syndrome

Sample item

A 45-year-old with polyostotic fibrous dysplasia develops painless, slowly growing intramuscular masses in the thigh, which on biopsy are myxomas. What is this association called?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Mazabraud syndrome

Mazabraud syndrome is fibrous dysplasia with intramuscular myxomas, both linked to activating GNAS mutations. The myxomas usually lie near the dysplastic bone and are treated by simple excision if symptomatic.

Option by option

  • A. Mazabraud syndrome (correct)

    Correct. Fibrous dysplasia together with intramuscular myxoma defines this syndrome.

  • B. Maffucci syndrome

    Maffucci syndrome combines enchondromas with soft tissue haemangiomas.

  • C. McCune-Albright syndrome

    McCune-Albright syndrome combines polyostotic fibrous dysplasia, cafe-au-lait spots and endocrine hyperfunction.

  • D. Jaffe-Campanacci syndrome

    Jaffe-Campanacci syndrome combines multiple non-ossifying fibromas with cafe-au-lait spots.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Orthopaedics question

What is the answer to this Orthopaedics question?

The best answer is A, Mazabraud syndrome. Mazabraud syndrome is fibrous dysplasia with intramuscular myxomas, both linked to activating GNAS mutations.

Why is "Maffucci syndrome" not the answer?

Maffucci syndrome combines enchondromas with soft tissue haemangiomas.

Why is "McCune-Albright syndrome" not the answer?

McCune-Albright syndrome combines polyostotic fibrous dysplasia, cafe-au-lait spots and endocrine hyperfunction.

Why is "Jaffe-Campanacci syndrome" not the answer?

Jaffe-Campanacci syndrome combines multiple non-ossifying fibromas with cafe-au-lait spots.

What concept does this question test?

It tests Bone tumours: Mazabraud syndrome in Orthopaedics. The myxomas usually lie near the dysplastic bone and are treated by simple excision if symptomatic.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Bone tumours: Mazabraud syndrome?

Pair each fracture with its classic complication and nerve injured. Then use the flashcards and the other Orthopaedics questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.