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Psychiatry · Substance use: cannabinoid hyperemesis syndrome
Sample itemA 26-year-old man who has smoked cannabis daily for years has recurrent episodes of intense nausea, repeated vomiting and abdominal pain. He finds that long hot showers temporarily relieve the symptoms, and routine investigations are normal. What is the most likely diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Cannabinoid hyperemesis syndrome
Cannabinoid hyperemesis syndrome develops in long-term heavy users and produces cyclical vomiting with compulsive hot bathing for relief. Antiemetics are often ineffective, and resolution needs sustained cannabis cessation.
Option by option
A. Gastroparesis
Gastroparesis causes postprandial fullness and early satiety with delayed emptying, not relief from hot showers.
B. Bulimia nervosa
Bulimia nervosa involves self-induced vomiting with body-image concern and binge eating.
C. Superior mesenteric artery syndrome
Superior mesenteric artery syndrome occurs after marked weight loss and causes postprandial duodenal obstruction.
D. Cannabinoid hyperemesis syndrome (correct)
Correct. Chronic daily cannabis use with cyclical vomiting relieved by hot water is typical.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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