Inhalational agents: methoxyflurane: practice question

A Anaesthesia question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anaesthesia · Inhalational agents: methoxyflurane

Sample item

Prolonged use of methoxyflurane for analgesia is limited by which toxicity?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Nephrotoxicity from inorganic fluoride

Methoxyflurane is extensively metabolised and releases inorganic fluoride, causing high-output renal failure. Low-dose use as an analgesic has regained interest because the dose is small.

Option by option

  • A. Pulmonary fibrosis

    Pulmonary fibrosis is not a feature.

  • B. Seizures

    Seizures are linked to enflurane.

  • C. Nephrotoxicity from inorganic fluoride (correct)

    Correct. Fluoride causes renal injury.

  • D. Hepatitis

    Hepatitis is the problem with halothane.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Anaesthesia question

What is the answer to this Anaesthesia question?

The best answer is C, Nephrotoxicity from inorganic fluoride. Methoxyflurane is extensively metabolised and releases inorganic fluoride, causing high-output renal failure.

Why is "Pulmonary fibrosis" not the answer?

Pulmonary fibrosis is not a feature.

Why is "Seizures" not the answer?

Seizures are linked to enflurane.

Why is "Hepatitis" not the answer?

Hepatitis is the problem with halothane.

What concept does this question test?

It tests Inhalational agents: methoxyflurane in Anaesthesia. Low-dose use as an analgesic has regained interest because the dose is small.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Inhalational agents: methoxyflurane?

Make a table of each agent, its key advantage and its main side effect. Then use the flashcards and the other Anaesthesia questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.