Muscle relaxants: drug interactions: practice question

A Anaesthesia question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anaesthesia · Muscle relaxants: drug interactions

Sample item

Which drug potentiates non-depolarising neuromuscular block?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Magnesium sulphate

Magnesium reduces prejunctional acetylcholine release and lowers postjunctional sensitivity. Aminoglycosides, volatile agents and local anaesthetics also potentiate block, while chronic anticonvulsants cause resistance.

Option by option

  • A. Phenytoin chronic therapy

    Chronic phenytoin causes resistance.

  • B. Carbamazepine chronic therapy

    Chronic carbamazepine causes resistance.

  • C. Calcium chloride

    Calcium antagonises the block.

  • D. Magnesium sulphate (correct)

    Correct. Magnesium enhances block.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Anaesthesia question

What is the answer to this Anaesthesia question?

The best answer is D, Magnesium sulphate. Magnesium reduces prejunctional acetylcholine release and lowers postjunctional sensitivity.

Why is "Phenytoin chronic therapy" not the answer?

Chronic phenytoin causes resistance.

Why is "Carbamazepine chronic therapy" not the answer?

Chronic carbamazepine causes resistance.

Why is "Calcium chloride" not the answer?

Calcium antagonises the block.

What concept does this question test?

It tests Muscle relaxants: drug interactions in Anaesthesia. Aminoglycosides, volatile agents and local anaesthetics also potentiate block, while chronic anticonvulsants cause resistance.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Muscle relaxants: drug interactions?

Make a table of each agent, its key advantage and its main side effect. Then use the flashcards and the other Anaesthesia questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.