Syndromes: Pendred syndrome: practice question

A ENT question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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ENT · Syndromes: Pendred syndrome

Sample item

A teenager has congenital bilateral sensorineural deafness and a diffuse goitre. Which test is used to support the diagnosis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Perchlorate discharge test

Pendred syndrome is autosomal recessive and involves an organification defect, with a positive perchlorate discharge test. The inner ear often shows Mondini dysplasia or an enlarged vestibular aqueduct. Patients are usually euthyroid or mildly hypothyroid.

Option by option

  • A. Serum calcitonin

    Calcitonin is a marker of medullary carcinoma.

  • B. Thyroid antibodies

    Antibodies point to autoimmune thyroid disease.

  • C. Radioiodine scan only

    A scan alone cannot show the organification defect.

  • D. Perchlorate discharge test (correct)

    Correct. A positive perchlorate discharge test supports Pendred syndrome.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this ENT question

What is the answer to this ENT question?

The best answer is D, Perchlorate discharge test. Pendred syndrome is autosomal recessive and involves an organification defect, with a positive perchlorate discharge test.

Why is "Serum calcitonin" not the answer?

Calcitonin is a marker of medullary carcinoma.

Why is "Thyroid antibodies" not the answer?

Antibodies point to autoimmune thyroid disease.

Why is "Radioiodine scan only" not the answer?

A scan alone cannot show the organification defect.

What concept does this question test?

It tests Syndromes: Pendred syndrome in ENT. The inner ear often shows Mondini dysplasia or an enlarged vestibular aqueduct. Patients are usually euthyroid or mildly hypothyroid.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Syndromes: Pendred syndrome?

Learn tuning fork results and audiogram patterns by sketching them. Then use the flashcards and the other ENT questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.