Nose: Kallmann syndrome: practice question

A ENT question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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ENT · Nose: Kallmann syndrome

Sample item

A 17-year-old boy has absent puberty and has never perceived smell. Which hormonal finding is expected?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Low GnRH-dependent gonadotropins (hypogonadotropic hypogonadism)

Kallmann syndrome results from failure of GnRH neurons to migrate with the olfactory placode, causing hypogonadotropic hypogonadism and anosmia. MRI shows absent olfactory bulbs. Treatment is hormone replacement.

Option by option

  • A. Low TSH

    TSH is not related.

  • B. Low GnRH-dependent gonadotropins (hypogonadotropic hypogonadism) (correct)

    Correct. Low gonadotropins with anosmia define Kallmann syndrome.

  • C. High FSH and LH

    High FSH and LH would indicate primary gonadal failure.

  • D. High prolactin

    Hyperprolactinaemia is not the mechanism.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this ENT question

What is the answer to this ENT question?

The best answer is B, Low GnRH-dependent gonadotropins (hypogonadotropic hypogonadism). Kallmann syndrome results from failure of GnRH neurons to migrate with the olfactory placode, causing hypogonadotropic hypogonadism and anosmia.

Why is "Low TSH" not the answer?

TSH is not related.

Why is "High FSH and LH" not the answer?

High FSH and LH would indicate primary gonadal failure.

Why is "High prolactin" not the answer?

Hyperprolactinaemia is not the mechanism.

What concept does this question test?

It tests Nose: Kallmann syndrome in ENT. MRI shows absent olfactory bulbs. Treatment is hormone replacement.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Nose: Kallmann syndrome?

Learn tuning fork results and audiogram patterns by sketching them. Then use the flashcards and the other ENT questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.