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ENT · Head and neck: risk factors
Sample itemWhich statement about alcohol and tobacco in head and neck cancer is correct?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Together they act synergistically and increase the risk of second primary tumours
Tobacco and alcohol have a multiplicative effect on cancers of the oral cavity, pharynx and larynx. Field cancerisation of the whole upper aerodigestive mucosa leads to synchronous and metachronous second primaries.
Option by option
A. Smoking cessation does not change risk
Cessation lowers risk over time.
B. Together they act synergistically and increase the risk of second primary tumours (correct)
Correct. The effect is synergistic with field cancerisation.
C. Alcohol alone has no effect
Alcohol is an independent risk factor.
D. Tobacco only affects the lung
Tobacco affects the whole upper aerodigestive tract.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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