Gestational trophoblastic disease: choriocarcinoma: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Gestational trophoblastic disease: choriocarcinoma

Sample item

Choriocarcinoma most commonly metastasises first to which organ?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Lungs

Choriocarcinoma is haematogenous, with the lungs being the commonest site (cannonball shadows), followed by vagina, brain and liver. It follows a mole in about 50 per cent of cases and responds extremely well to chemotherapy.

Option by option

  • A. Bone

    Bone is an uncommon site.

  • B. Liver

    The liver is involved in advanced disease.

  • C. Brain

    Brain metastases occur later and mark high-risk disease.

  • D. Lungs (correct)

    Correct. The lung is the commonest metastatic site.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is D, Lungs. Choriocarcinoma is haematogenous, with the lungs being the commonest site (cannonball shadows), followed by vagina, brain and liver.

Why is "Bone" not the answer?

Bone is an uncommon site.

Why is "Liver" not the answer?

The liver is involved in advanced disease.

Why is "Brain" not the answer?

Brain metastases occur later and mark high-risk disease.

What concept does this question test?

It tests Gestational trophoblastic disease: choriocarcinoma in OBG. It follows a mole in about 50 per cent of cases and responds extremely well to chemotherapy.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gestational trophoblastic disease: choriocarcinoma?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.