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OBG · Medical disorders in pregnancy: viral hepatitis E
Sample itemA woman at 32 weeks in a flood-affected area presents with jaundice and encephalopathy. Which infection carries a particularly high maternal mortality (up to 20 to 25 per cent) in the third trimester?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Hepatitis E
Hepatitis E is waterborne and causes fulminant hepatic failure in pregnancy, especially in the third trimester, with high maternal and fetal mortality. Management is supportive, with early delivery considered for deteriorating cases. Hepatitis A is rarely severe.
Option by option
A. Hepatitis C
Hepatitis C is chronic and rarely causes acute failure.
B. Hepatitis A
Hepatitis A usually has a benign course.
C. Cytomegalovirus
CMV rarely causes fulminant hepatitis in immunocompetent mothers.
D. Hepatitis E (correct)
Correct. Fulminant hepatitis E is typical of third-trimester pregnancy.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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