Complications of pregnancy: recurrent pregnancy loss: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Complications of pregnancy: recurrent pregnancy loss

Sample item

What is the most common cause of sporadic first-trimester pregnancy loss?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Fetal chromosomal abnormality

About 50 per cent of first-trimester losses are due to chromosomal abnormalities, mostly autosomal trisomies. Antiphospholipid syndrome is the commonest treatable cause of recurrent loss, and a septum is a structural cause.

Option by option

  • A. Maternal hypothyroidism

    Hypothyroidism is an uncommon cause.

  • B. Antiphospholipid syndrome

    APLA is the commonest treatable acquired cause of recurrent loss.

  • C. Fetal chromosomal abnormality (correct)

    Correct. Aneuploidy accounts for about half of early losses.

  • D. Uterine septum

    A septate uterus is a cause of recurrent loss but not the commonest cause.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this OBG question

What is the answer to this OBG question?

The best answer is C, Fetal chromosomal abnormality. About 50 per cent of first-trimester losses are due to chromosomal abnormalities, mostly autosomal trisomies.

Why is "Maternal hypothyroidism" not the answer?

Hypothyroidism is an uncommon cause.

Why is "Antiphospholipid syndrome" not the answer?

APLA is the commonest treatable acquired cause of recurrent loss.

Why is "Uterine septum" not the answer?

A septate uterus is a cause of recurrent loss but not the commonest cause.

What concept does this question test?

It tests Complications of pregnancy: recurrent pregnancy loss in OBG. Antiphospholipid syndrome is the commonest treatable cause of recurrent loss, and a septum is a structural cause.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Complications of pregnancy: recurrent pregnancy loss?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.