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OBG · Gynaecological endocrinology: coagulopathy
Sample itemA teenager has heavy menses since menarche, easy bruising and prolonged bleeding after dental extraction. Which is the commonest underlying bleeding disorder?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. von Willebrand disease
von Willebrand disease is the commonest inherited bleeding disorder and a frequent cause of heavy menstrual bleeding from menarche. Screening includes vWF antigen and activity, factor VIII level, and ristocetin cofactor. Desmopressin and tranexamic acid are used.
Option by option
A. Vitamin K deficiency
Vitamin K deficiency is acquired and uncommon in healthy adolescents.
B. von Willebrand disease (correct)
Correct. vWD is the commonest in this context.
C. Factor XIII deficiency
Factor XIII deficiency is rare.
D. Haemophilia A
Haemophilia A is X-linked and rarely affects women.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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