Gynaecological oncology: Sertoli-Leydig tumour: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Gynaecological oncology: Sertoli-Leydig tumour

Sample item

A young woman has amenorrhoea, deepening of voice, clitoromegaly and a unilateral ovarian mass. Which tumour is most likely?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Sertoli-Leydig cell tumour

Sertoli-Leydig cell tumours secrete androgens and cause defeminisation followed by masculinisation. Raised testosterone with a unilateral mass should prompt ovarian imaging. They are treated by unilateral oophorectomy in young women.

Option by option

  • A. Granulosa cell tumour

    Granulosa tumours are oestrogenic.

  • B. Dysgerminoma

    Dysgerminomas do not produce androgens.

  • C. Brenner tumour

    Brenner tumours are usually benign and hormone inactive.

  • D. Sertoli-Leydig cell tumour (correct)

    Correct. Virilisation with an ovarian mass is typical.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this OBG question

What is the answer to this OBG question?

The best answer is D, Sertoli-Leydig cell tumour. Sertoli-Leydig cell tumours secrete androgens and cause defeminisation followed by masculinisation.

Why is "Granulosa cell tumour" not the answer?

Granulosa tumours are oestrogenic.

Why is "Dysgerminoma" not the answer?

Dysgerminomas do not produce androgens.

Why is "Brenner tumour" not the answer?

Brenner tumours are usually benign and hormone inactive.

What concept does this question test?

It tests Gynaecological oncology: Sertoli-Leydig tumour in OBG. Raised testosterone with a unilateral mass should prompt ovarian imaging. They are treated by unilateral oophorectomy in young women.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gynaecological oncology: Sertoli-Leydig tumour?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.