Glaucoma: prostaglandin analogues: practice question

A Ophthalmology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Ophthalmology · Glaucoma: prostaglandin analogues

Sample item

A patient started on latanoprost develops darkening of the iris and longer eyelashes. What is the mechanism of the drug's pressure-lowering effect?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Increased uveoscleral outflow

Prostaglandin F2 alpha analogues remodel the ciliary muscle extracellular matrix and increase uveoscleral outflow. They are administered once daily at night, and side effects include iris pigmentation and hyperaemia.

Option by option

  • A. Osmotic dehydration

    Osmotic agents like mannitol dehydrate the vitreous.

  • B. Increased uveoscleral outflow (correct)

    Correct. They increase uveoscleral outflow.

  • C. Miosis and increased trabecular outflow

    Pilocarpine increases trabecular outflow through ciliary muscle contraction.

  • D. Reduced aqueous production

    Beta-blockers and CA inhibitors reduce production.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Ophthalmology question

What is the answer to this Ophthalmology question?

The best answer is B, Increased uveoscleral outflow. Prostaglandin F2 alpha analogues remodel the ciliary muscle extracellular matrix and increase uveoscleral outflow.

Why is "Osmotic dehydration" not the answer?

Osmotic agents like mannitol dehydrate the vitreous.

Why is "Miosis and increased trabecular outflow" not the answer?

Pilocarpine increases trabecular outflow through ciliary muscle contraction.

Why is "Reduced aqueous production" not the answer?

Beta-blockers and CA inhibitors reduce production.

What concept does this question test?

It tests Glaucoma: prostaglandin analogues in Ophthalmology. They are administered once daily at night, and side effects include iris pigmentation and hyperaemia.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Glaucoma: prostaglandin analogues?

Group the red eye by what to examine and what the pupil does. Then use the flashcards and the other Ophthalmology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.