Uveitis: HLA association: practice question

A Ophthalmology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Ophthalmology · Uveitis: HLA association

Sample item

A young man with low back pain and recurrent unilateral acute anterior uveitis with fibrin is most likely to have which HLA type?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. HLA-B27

HLA-B27 is associated with acute anterior uveitis and spondyloarthropathies such as ankylosing spondylitis. Attacks alternate between eyes.

Option by option

  • A. HLA-A29

    HLA-A29 is linked to birdshot chorioretinopathy.

  • B. HLA-DR4

    HLA-DR4 is linked to rheumatoid arthritis and VKH.

  • C. HLA-B51

    HLA-B51 is linked to Behcet disease.

  • D. HLA-B27 (correct)

    Correct. This pattern of disease is linked to HLA-B27.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Ophthalmology questions

Questions about this Ophthalmology question

What is the answer to this Ophthalmology question?

The best answer is D, HLA-B27. HLA-B27 is associated with acute anterior uveitis and spondyloarthropathies such as ankylosing spondylitis.

Why is "HLA-A29" not the answer?

HLA-A29 is linked to birdshot chorioretinopathy.

Why is "HLA-DR4" not the answer?

HLA-DR4 is linked to rheumatoid arthritis and VKH.

Why is "HLA-B51" not the answer?

HLA-B51 is linked to Behcet disease.

What concept does this question test?

It tests Uveitis: HLA association in Ophthalmology. Attacks alternate between eyes.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Uveitis: HLA association?

Group the red eye by what to examine and what the pupil does. Then use the flashcards and the other Ophthalmology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.