Bone tumours: aneurysmal bone cyst: practice question

A Orthopaedics question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Orthopaedics · Bone tumours: aneurysmal bone cyst

Sample item

MRI of a vertebral lesion shows multiple cystic spaces with fluid-fluid levels in a 12-year-old. Which gene rearrangement is commonly present in primary lesions of this type?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. USP6 rearrangement

Aneurysmal bone cyst is an expansile blood-filled cystic lesion with fluid-fluid levels due to haemorrhage. Primary lesions harbour USP6 translocations, indicating they are neoplastic. Treatment is curettage with grafting, with embolisation or sclerotherapy options.

Option by option

  • A. SS18-SSX fusion

    SS18-SSX is the synovial sarcoma fusion.

  • B. EWSR1-FLI1 fusion

    EWSR1-FLI1 is the Ewing sarcoma fusion.

  • C. IDH1 mutation

    IDH1 mutations occur in enchondroma and chondrosarcoma.

  • D. USP6 rearrangement (correct)

    Correct. USP6 rearrangement is characteristic of primary ABC.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Orthopaedics question

What is the answer to this Orthopaedics question?

The best answer is D, USP6 rearrangement. Aneurysmal bone cyst is an expansile blood-filled cystic lesion with fluid-fluid levels due to haemorrhage.

Why is "SS18-SSX fusion" not the answer?

SS18-SSX is the synovial sarcoma fusion.

Why is "EWSR1-FLI1 fusion" not the answer?

EWSR1-FLI1 is the Ewing sarcoma fusion.

Why is "IDH1 mutation" not the answer?

IDH1 mutations occur in enchondroma and chondrosarcoma.

What concept does this question test?

It tests Bone tumours: aneurysmal bone cyst in Orthopaedics. Primary lesions harbour USP6 translocations, indicating they are neoplastic. Treatment is curettage with grafting, with embolisation or sclerotherapy options.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Bone tumours: aneurysmal bone cyst?

Pair each fracture with its classic complication and nerve injured. Then use the flashcards and the other Orthopaedics questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.