Immunisation: typhoid conjugate vaccine: practice question

A Pediatrics question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pediatrics · Immunisation: typhoid conjugate vaccine

Sample item

Which statement about the typhoid conjugate vaccine under IAP recommendations is correct?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. It can be given from 6 months of age with a booster at 2 years

IAP recommends Vi-TCV from 6 months with a single dose and a booster at 2 years. Conjugation to a carrier protein gives T-cell dependent immunity, unlike Vi polysaccharide which is not effective below 2 years. Oral Ty21a is a live capsule vaccine for older children.

Option by option

  • A. It is an oral live vaccine

    TCV is an injectable vaccine.

  • B. It is contraindicated before 2 years

    Conjugate vaccines work in infants, unlike plain polysaccharide.

  • C. It can be given from 6 months of age with a booster at 2 years (correct)

    Correct. TCV may be given from 6 months.

  • D. It must be given every year

    Annual dosing is not required.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pediatrics question

What is the answer to this Pediatrics question?

The best answer is C, It can be given from 6 months of age with a booster at 2 years. IAP recommends Vi-TCV from 6 months with a single dose and a booster at 2 years.

Why is "It is an oral live vaccine" not the answer?

TCV is an injectable vaccine.

Why is "It is contraindicated before 2 years" not the answer?

Conjugate vaccines work in infants, unlike plain polysaccharide.

Why is "It must be given every year" not the answer?

Annual dosing is not required.

What concept does this question test?

It tests Immunisation: typhoid conjugate vaccine in Pediatrics. Conjugation to a carrier protein gives T-cell dependent immunity, unlike Vi polysaccharide which is not effective below 2 years. Oral Ty21a is a live capsule vaccine for older children.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Immunisation: typhoid conjugate vaccine?

Memorise milestones and the vaccine schedule as tables and revise them often. Then use the flashcards and the other Pediatrics questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.