Oncology: ALL prognosis: practice question

A Pediatrics question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pediatrics · Oncology: ALL prognosis

Sample item

Which feature in a child with ALL indicates a good prognosis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Age 2 to 10 years with hyperdiploidy

Favourable features include age between 1 and 10 years, low WBC at presentation, female sex, hyperdiploidy and the t(12;21) translocation, and a rapid response to induction. Poor features are infancy, high WBC, t(9;22), t(4;11) and CNS disease. Risk stratification guides treatment intensity.

Option by option

  • A. Philadelphia chromosome positivity

    Philadelphia chromosome carries a poor outlook.

  • B. Presenting WBC above 100,000

    High WBC is a poor prognostic marker.

  • C. Age 2 to 10 years with hyperdiploidy (correct)

    Correct. Hyperdiploidy at 2 to 10 years is favourable.

  • D. Age under 1 year

    Infant ALL has a poor prognosis.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pediatrics question

What is the answer to this Pediatrics question?

The best answer is C, Age 2 to 10 years with hyperdiploidy. Favourable features include age between 1 and 10 years, low WBC at presentation, female sex, hyperdiploidy and the t(12;21) translocation, and a rapid response to induction.

Why is "Philadelphia chromosome positivity" not the answer?

Philadelphia chromosome carries a poor outlook.

Why is "Presenting WBC above 100,000" not the answer?

High WBC is a poor prognostic marker.

Why is "Age under 1 year" not the answer?

Infant ALL has a poor prognosis.

What concept does this question test?

It tests Oncology: ALL prognosis in Pediatrics. Poor features are infancy, high WBC, t(9;22), t(4;11) and CNS disease. Risk stratification guides treatment intensity.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Oncology: ALL prognosis?

Memorise milestones and the vaccine schedule as tables and revise them often. Then use the flashcards and the other Pediatrics questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.