Schizophrenia: genetics: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Psychiatry · Schizophrenia: genetics

Sample item

Approximately what is the concordance rate for schizophrenia in monozygotic twins?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. 40 to 50 percent

Monozygotic concordance is about 40 to 50 percent, far above dizygotic twins (around 10 to 15 percent) and the general population risk of about 1 percent. Since it is under 100 percent, environmental factors also contribute.

Option by option

  • A. About 5 percent

    Five percent is closer to the risk in second-degree relatives.

  • B. Under 1 percent

    Under one percent is below even the general population risk.

  • C. 40 to 50 percent (correct)

    Correct. Concordance is around 40 to 50 percent.

  • D. Nearly 100 percent

    Concordance is not near 100 percent, otherwise the disorder would be purely genetic.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is C, 40 to 50 percent. Monozygotic concordance is about 40 to 50 percent, far above dizygotic twins (around 10 to 15 percent) and the general population risk of about 1 percent.

Why is "About 5 percent" not the answer?

Five percent is closer to the risk in second-degree relatives.

Why is "Under 1 percent" not the answer?

Under one percent is below even the general population risk.

Why is "Nearly 100 percent" not the answer?

Concordance is not near 100 percent, otherwise the disorder would be purely genetic.

What concept does this question test?

It tests Schizophrenia: genetics in Psychiatry. Since it is under 100 percent, environmental factors also contribute.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Schizophrenia: genetics?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.