Antipsychotics: risperidone: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Psychiatry · Antipsychotics: risperidone

Sample item

Among second-generation antipsychotics, which one is most strongly associated with raised serum prolactin at usual doses?

ARisperidoneBClozapineCAripiprazoleDQuetiapine

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Risperidone

Risperidone, together with its metabolite paliperidone, and amisulpride cause the most prolactin elevation among atypicals. Quetiapine, clozapine and aripiprazole cause little or none.

Option by option

A. Risperidone (correct)
Correct. Risperidone commonly raises prolactin.
B. Clozapine
Clozapine seldom raises prolactin.
C. Aripiprazole
Aripiprazole is a partial agonist and tends to lower prolactin.
D. Quetiapine
Quetiapine has only a transient and minor effect.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is A, Risperidone. Risperidone, together with its metabolite paliperidone, and amisulpride cause the most prolactin elevation among atypicals.

Why is "Clozapine" not the answer?

Clozapine seldom raises prolactin.

Why is "Aripiprazole" not the answer?

Aripiprazole is a partial agonist and tends to lower prolactin.

Why is "Quetiapine" not the answer?

Quetiapine has only a transient and minor effect.

What concept does this question test?

It tests Antipsychotics: risperidone in Psychiatry. Quetiapine, clozapine and aripiprazole cause little or none.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antipsychotics: risperidone?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.