Antipsychotics: ziprasidone: practice question

A Psychiatry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Psychiatry · Antipsychotics: ziprasidone

Sample item

To ensure adequate absorption, the oral antipsychotic ziprasidone should be taken:

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. With a meal of adequate calories

The bioavailability of ziprasidone roughly doubles when taken with food, so the dose should accompany a meal. It also has a notable QT-prolonging effect and a relatively neutral weight profile.

Option by option

  • A. On an empty stomach

    Fasting reduces absorption.

  • B. With a meal of adequate calories (correct)

    Correct. Food markedly improves ziprasidone absorption.

  • C. With grapefruit juice

    Grapefruit juice inhibits CYP3A4 and is not a recommended way to take it.

  • D. Only at bedtime without food

    Taking it without food lowers exposure.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Psychiatry question

What is the answer to this Psychiatry question?

The best answer is B, With a meal of adequate calories. The bioavailability of ziprasidone roughly doubles when taken with food, so the dose should accompany a meal.

Why is "On an empty stomach" not the answer?

Fasting reduces absorption.

Why is "With grapefruit juice" not the answer?

Grapefruit juice inhibits CYP3A4 and is not a recommended way to take it.

Why is "Only at bedtime without food" not the answer?

Taking it without food lowers exposure.

What concept does this question test?

It tests Antipsychotics: ziprasidone in Psychiatry. It also has a notable QT-prolonging effect and a relatively neutral weight profile.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antipsychotics: ziprasidone?

Learn each diagnosis by its core features and its first-line treatment. Then use the flashcards and the other Psychiatry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.